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Commonly referred to as the “spirit molecule,” DMT is best known for its ability to induce dreamlike states of consciousness.

This naturally-produced molecule produces intense visions of bright kaleidoscope fractals and blurs the lines between what we consider “self” to be. It warps our perception of time and space, induces life-altering insights, and expands the mind in ways you would never have thought possible.

What is DMT (Dimethyltryptamine)?

DMT is an acronym for N,N-dimethyltryptamine. It’s a naturally-occurring alkaloid found throughout nature. Trace amounts of this molecule can be found in various plant and animal species. The human brain manufactures its own DMT in the pineal gland.

DMT, the drug, comes in a few different forms:

  • A crystalline powder that can be smoked or vaped for a powerful hallucinogenic experience
  • A dark brown, bitter-tasting brew called ayahuasca
  • A brownish herb mixture called changa

DMT: Specs & Technical Details

Chemical NameN,N-Dimethyltryptamine
Level of RiskLow
Street NamesDimitri, The Spirit Molecule, God Molecule
Most Common Side-EffectsAnxiety, paranoia, & nausea
Duration of Effects15 – 20 minutes
LegalityIllegal Globally

There Are 3 Different Types of DMT namely; N,N-DMT, 5-MeO DMT, 4-AcO DMT

N,N-DMT

(N,N-Dimethyltryptamine)

This is the form of DMT most abundant in the natural world — including the human brain. When you drink a brew of ayahuasca, this is the predominant form of DMT you’ll be using.

This form of DMT has a strong visual component but can also lead users to dissociate from reality.

Compared to the other forms of DMT, it’s somewhere in the middle in terms of strength. 5-MeO-DMT is the strongest, while 4-AcO-DMT is the weakest.

5-MeO DMT

(5-methoxy-Dimethyltryptamine)

This form of DMT is differentiated from N,N-DMT by its short duration of effects (10 – 20 minutes in total) and extreme potency. 5-MeO-DMT is roughly six times as potent as N,N-DMT, and has much less of a visual component.

This version of DMT can be found in nature in a handful of plants such as Mucuna pruriens, Mimosa pudica, Anadenanthera peregrina (yopo), and a few species of cacti. It’s also found in a couple of mushroom species (Amanita citrina and Amanita porphyra) and some toads. 

The most famous source of this type of DMT is the Sonoran Desert Toad (Bufo alvarius). This particular toad secretes 5-MeO-DMT, and a related compound called bufotenin as a defense mechanism to avoid being eaten by other animals. Along with DMT, these toads secrete a series of toxic compounds that can make using this toad dangerous if not prepared properly.

The use of these toads secretions or skin is a traditional sacrament called chansu. It involves ingesting or smoking the secretion to produce a psychoactive state.

5-MeO-DMT is also available in synthetic form, which can be snorted, smoked, or injected. This is the most sustainable, most affordable, and most common form of 5-MeO-DMT.

Oral forms of 5-MeO-DMT are also available but must be combined with an MAO (monoamine oxidase) inhibitor in order for it to work. MAO is an enzyme produced by the body that primarily works to break down neurotransmitters like serotonin and dopamine, but it also destroys DMT in the gut before it’s absorbed.

When combined with a compound that inhibits MAO, the effects of DMT appear within minutes. This quickly evolves into intense visuals and out of body experiences. Many users report living through several lifetimes after a single 15 minute trip on 5-MeO-DMT. Others experience contact with “beings from other realms,” or intense introspection or ego death.

4-AcO DMT

(4-Acetoxy-N,N-dimethyltryptamine)

4-AcO-DMT is more closely related to psilocin — the active ingredient in magic mushrooms — than it is to the other forms of DMT. In fact, this compound is considered a prodrug of psilocin.

This means 4-AcO-DMT is converted into psilocybin by the body. The majority of this drug’s effects begin once it’s converted into psilocin by the liver. However, it also has some psychoactive effects on its own. Users who smoke 4-AcO-DMT report mild to moderate psychoactivity beginning within seconds. These effects can only come from the drug itself since inhalation bypasses first-pass liver metabolism — meaning it hasn’t yet been metabolized by the liver.

This form of DMT is not found in nature. It’s a semi-synthetic molecule, which means it’s made by modifying other compounds in a lab setting.

The effects of this psychedelic are very similar to magic mushrooms. It produces distortions in visual and auditory sensation, induces states of introspection, and can result in separation from ego in higher doses.

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