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How Strong is DMT Compared to Other Psychedelics?

DMT is one of the most powerful psychedelic compounds on earth. N,N-DMT (found in ayahuasca) is rated at an 8 out of 10 on the psychedelic scale, while 5-MeO-DMT falls closer to 10/10.

So how does DMT compare to other psychedelics?


DMT and LSD share a similar structure, and both interact with the 5HT2A receptors to produce most of their psychedelic effects.

In general, the effects of both of these drugs are very similar, but DMT is stronger from a psychoactive perspective. You’re much more likely to have an out of body experience on DMT than LSD.

DMT vs. Psilocybin

N,N-DMT, and 5-MeO-DMT are very different from psilocybin and psilocin in their effects. Psilocybin is known for producing a stronger “body high” with less visual components.

These forms of DMT, on the other hand, have a stronger visual component and out of body experiences.

4-AcO-DMT is the exception here. Its effects are very similar, if not identical, to psilocybin.

DMT vs. Ketamine

Ketamine works through completely different receptors compared to DMT, and therefore the effects are going to be very different.

Both DMT and ketamine can produce out of body experiences, but there are a lot of differences between the two. The DMT experience is otherworldly and highly introspective at times. Ketamine, on the other hand, is best described as “shadowy” or “muffled.” It numbs the body and makes you feel as though you’re more of a spectator than experiencing the trip first hand.

In lower doses, ketamine feels very different and has much less visual component than DMT.

DMT vs. Mescaline

Mescaline has similar hallucinatory effects as DMT, but with a twist. This compound interacts much more strongly with the dopamine receptors, rather than focusing specifically on the serotonin receptors like DMT, LSD, or psilocybin.

So what does this mean in terms of effects?

Mescaline has a strong visual component and can result in a lot of introspective thoughts — but even in high doses, mescaline users remain coherent and clear-headed. Thoughts can be chaotic at times, and the change in perception can affect how we experience time, but at no point do we leave the body or experience ego death.

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