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What is LSD, and why do its effects last so long?

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Lysergic acid diethylamide (LSD), or acid as it’s commonly known, is a potent, long-lasting psychoactive drug. In part, it’s derived from a fungus that grows on rye and other grains.

The synthetic drug has a chemical structure similar to serotonin, a “feel-good” chemical in your brain.

When acid molecules land on serotonin receptors, they cause LSD’s well-known visual and physical effects. This includes color and shape distortions, hallucinations, and other psychedelic effects.

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LSD molecules bind more strongly to serotonin receptors than serotonin itself. When the molecules nestle into the receptor pockets, amino acids within the receptor put a “lid” over the molecules. This traps the molecules in place.

The drug’s effects won’t begin to fade until the molecules are knocked off or come loose from the serotonin receptor. This can take anywhere from 6 to 15 hours. It all depends on the potency of the drug, your size, and any other medications you might be taking.

How is it used, and is it safe to ingest?

Acid is a colorless, odorless liquid. For consumption, an acid manufacturer typically drips the liquid onto absorbent, colorful paper squares called blotter papers. Each blotter paper can have several “tabs.” One tab is usually enough to induce a trip.

LSD is also sometimes sold as capsules, pills, or sugar cubes. In each form, LSD is diluted with other chemicals or products. Potency for each LSD product varies. There’s virtually no way to know how much LSD is in any form you take.

LSD is considered a safe and nontoxic drug when taken at standard doses. LSD toxicity, or death from LSD, is rare.

You’re more likely to have a “bad trip” — a distressing psychedelic episode — than you are to experience physical harm.

Are dosage guidelines available?

For most people, a dose of 1 to 3 micrograms per kilogram of body weight is enough to produce a moderate trip.

If you haven’t used acid before, starting with a smaller dose may be a safer way to determine how your body handles the drug. Heavy doses of LSD can create intense highs that make you uncomfortable or nauseous.

Without chemical testing, it’s impossible to know how much LSD is in any product you choose to take. However, a quarter-inch tab from a blotter paper typically contains 30 to 100 micrograms.

An LSD gelatin, or “window pane,” may contain slightly more acid per piece. They usually contain anywhere from 50 to 150 micrograms.

Liquid LSD is very potent. You should avoid taking it directly unless you know how diluted it is.

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